RESEARCH


The Labex GR-Ex program focuses on different aspects of normal and pathologic red blood cells.

To elucidate regulation of normal erythropoiesis and underline mechanisms of disordered erythropoiesis to understand pathologies of red cell production.

GENERAL AIMS


CASPASES IN ERYTHROPOIESIS

ERYTHROID DIFFERENTIATION, RIBOSOMES AND P53

MEMBRANE TRANSPORTERS AND ERYTHROPOIESIS

NEW CANDIDATE GENES RESPONSIBLE FOR DISORDERED ERYTHROPOIESIS AND DEVELOPMENT OF NOVEL GENE THERAPY APPROCHES

To explore molecular mechanisms involved in maintaining body iron balance through the cross-talk between erythropoiesis, hepcidin synthesis and iron availability and their applications to tissue hypoxia, anemias of chronic disorders.

 

GENERAL AIMS


CROSS -TALK BETWEEN ERYTHROBLASTS, MACROPHAGES AND IRON HOMEOSTASIS

IRON AND THE CONTROL OF ERYTHROPOIESIS BY HYPOXIA

ANEMIA OF INFLAMMATION

To develop new therapeutic strategies based on adhesive and rheological properties of the abnormal blood cells on two diseases affecting the mature RBC and leading to major morbidity and mortality worldwide. New epidemiological studies will focus on the development of large cohorts of sickle cell disease (SCD) individuals to evaluate the morbid impact of SCD on cardiovascular, renal and neurological functions.

GENERAL AIMS


MALARIA: ADHESION AND SPLENIC RETENTION PROPERTIES OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES: RELATIONSHIP WITH THE SICKLE TRAIT

MALARIA: ADHESION AND SPLENIC RETENTION PROPERTIES OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES: RELATIONSHIP WITH THE SICKLE TRAIT

EPIDEMIOLOGY OF SICKLE CELL DISEASE: SCD REGISTRY AND CARDIOVASCULAR DISEASES IN A LARGE COHORT IN AFRICA

Supply of human allogeneic blood products is hampered by many constraints that can lead to shortages for patients, notably RBCs for transfusion during medical practice. Improvement/optimization of transfusion quality and new sources of RBCs/oxygen carriers would considerably improve the overall capacity of the global blood transfusion network.

GENERAL AIMS


OPTIMIZATION OF CLASSICAL RBC PRODUCT

DEVELOPMENT OF BLOOD SUBSTITUTES