The GR-Ex program focuses on different aspects of normal and pathologic red blood cells with an emphasis on translational research in non-malignant hematology.

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Researchers in 13 University Campuses and Institutions
Research Teams


The new Executive Committee (EC) is composed of 3 members: Olivier Hermine (coordinator of the program), Caroline Le Van Kim and Laurent Gouya. EC meetings will be held twice a year, each March with the Scientific Advisory Board and each September.
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New program coming up soon.

See results of the first year


The Labex GR-Ex is pleased to announce the launch of the 2nd Training Course on red blood cells: genesis to pathophysiology in collaboration with the European School of Hematology (ESH), October 28-30, 2016.

Laboratory of Excellence GR-Ex

The GR-Ex project

Over the past two decades, although dealing with important basic and clinical challenges, the field of red cell biogenesis has become neglected among young physicians and the scientific community.

Thus, the GR-Ex project stemmed from the idea to both unite the most talented research groups working in the field of erythropoiesis and to attract new scientists from other fields to the red blood cells and iron metabolism.

The Labex GR-Ex consortium

Currently, the Labex GR-Ex is comprised of 32 research groups, including researchers and clinicians, some being new to red cells. The core mission of the GR-Ex is to comprehensively investigate physiology and pathologies of erythropoiesis, red cells and iron metabolism.

GR-Ex Core Facilities

Biophotonic, Flow Adhesion and Cytometry core facility

Since 2007, the BioFACy-lity platform (UMR-S665, INTS) proposes the expertise and the innovative equipment to guarantee the support and the development aid of scientific projects exploiting the biophotonic imaging, the microfluidic and the flow cytometry. The up-to-date flow cell adhesion platform is perfectly suited to screen anti-adhesive therapeutic molecules.

The Prof. Patrick Mayeux (UMR-S1016) is the scientific responsible of the Paris Descartes proteomic facility (3P5) that is open to all research teams either public or private.

The team of Prof. Paul Henri Romeo at the CEA (UMR-S967) has unique expertise in metabolomic analysis of human red blood cells. The metabolomic platform is also accessible for industrials that are interested in the metabolome of human RBC.

The team of the Prof. Pierre Buffet (UMR-S945) features a semi high throughput filtration system. Red blood cells are filtered through microsphere layers “microsphiltration” that are adapted to microplates for screening purposes.

The university of Bordeaux Segalen (Prof. Hubert de Verneuil, UMR S-1035) features a platform dedicated to the production of lentiviral and AAV vectors.

Dr. Philippe Noirez (IRMES) will be responsible to install and develop the facility located at the University Center of Les Saints Pères, Paris Descartes University. During exercise and training we propose to measure O2 uptake, CO2 production, respiratory quotient and animals physical performance. Non-invasive “Whole Body Composition” will allow us to determine lean mass, fat, free body fluid content and total body water of mice by MNR.